Tuesday, May 14, 2013

Android chief says Google I/O will focus on devs, not new products

Google Sundar Pichai D10

Sundar Pichai, Andy Rubin's replacement as Android chief, has been talking to Wired about his new job. He poured ice water on the idea that we'll see a raft of new hardware at Google I/O, the company's annual developer conference. Instead, he said that this year's show will focus on "all of the kinds of things we're doing for developers, so that they can write better things" for Android and Chrome OS. He also let slip that his daily driver is a Galaxy S 4, but that he's never even used the flagship's much-hyped eye-tracking feature -- an admission which'll surely go down well with HTC One fans.

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Source: Wired

Source: http://www.engadget.com/2013/05/13/sundar-pichai-interview-google-io/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Monday, May 13, 2013

Researchers identifies gene associated with eczema in dogs

Sunday, May 12, 2013

A novel gene associated with canine atopic dermatitis has been identified by a team of researchers led by professors Kerstin Lindblad-Toh, Uppsala university and ?ke Hedhammar, SLU, Sweden. The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.

Details appear today in the open-access journal PLoS Genetics.

Atopic dermatitis (or eczema) is an inflammatory, relapsing non-contagious skin disease affecting about 10-30 percent of the human population. It is not only humans that suffer from the disease: about 3-10 percent of dogs are also affected. The skin of a patient with atopic dermatitis becomes easily irritated by various allergens such as certain types of food, pollens or house mites. Such irritation causes very strong itching which leads to scratching, redness and flaky skin that becomes vulnerable to bacterial and yeast infections.

To-date, despite many scientific efforts, little has been known about the genetics of the disease. In their study, researchers from Uppsala University, SLU and Broad Institute, compared DNA samples from a large group of German shepherd dogs affected by atopic dermatitis with DNA coming from healthy dogs to reveal the specific DNA segment associated with the disease.

"With the help of pet owners, we have managed to collect a unique set of DNA samples from sick and healthy dogs which allowed us to gain insight into atopic dermatitis genetics," said first author Katarina Tengvall, Uppsala University.

Purebred dogs such as German shepherds have been selected for specific physical features for several generations. Selection led to an inadvertent enrichment for disease-risk genes in certain breeds. Moreover, the resulting architecture of canine DNA makes it easier to pinpoint segments that carry these disease risk-genes. This helped the researchers to reveal the genetics of atopic dermatitis. They found a region associated with the atopic dermatitis containing the gene PKP-2, which encodes Plakophilin-2, a protein involved in the formation and maintaining of the proper skin structure.

"The finding that certain variants of the PKP-2 gene may increase the risk of developing the disease opens new possibilities in understanding the disease mechanism leading to atopic dermatitis," continues Katarina Tengvall.

These findings will not only lead to better understanding of the disease, which may lead to better treatment strategies long term. It also opens up the possibilities of development of a genetic test for the disease.

"Our study suggests that plakophilin-2 and an intact skin barrier is important to avoid atopic dermatitis", says senior author, Kerstin Lindblad-Toh, professor at Uppsala University and Director of SciLifeLab Uppsala. "Another gene involved in the skin barrier has recently been linked to human atopic dermatitis emphasizing the similarity between canine and human atopic dermatitis" continues Kerstin Lindblad-Toh.

###

Uppsala University: http://www.uu.se

Thanks to Uppsala University for this article.

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Source: http://www.labspaces.net/128185/Researchers_identifies_gene_associated_with_eczema_in_dogs

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Sunday, May 12, 2013

Pedro Castro: ?If I knew, I would have reported it?brother or no brother?

Onil and Pedro Castro (CNN)

The brothers of accused kidnapper and rapist Ariel Castro broken their public silence, giving CNN what's billed as an exclusive sit-down interview about the case.

Pedro, 54, and Onil Casto, 50, told CNN's Martin Savidge that they had no knowledge of their 52-year-old brother's alleged crimes.

"It?s going to haunt me down because people going to think, 'Yeah, Pedro got something to do with this,'" Pedro Castro said in an excerpt from the interview released Sunday. "And Pedro don?t have nothing to do with this. If I knew, I would have reported it?brother or no brother.?

The full interview with the brothers will air Monday, one week after three women?Michelle Knight, Amanda Berry, and Gina DeJesus?were freed from Ariel Castro's west Cleveland home where they were beaten and raped over a decade of captivity, police say. A six-year-old girl, believed to be Berry and Ariel Castro's, was also rescued.

The women had several miscarriages during their captivity, police said.

Pedro, Onil and Ariel Castro were arrested on Monday. Pedro and Onil were questioned and held on on outstanding misdemeanors. They were released on Thursday. Ariel Castro was charged with four counts of kidnapping and three counts of rape. He is being held on $8 million bail and is currently on suicide watch.

In 2012, as excavating crews dug through an empty lot in the neighborhood looking for Berry's remains, Pedro Castro told a local news crew that the search for the missing girl was "a waste of money."

Source: http://news.yahoo.com/blogs/lookout/pedro-castro-onil-cleveland-interview-132025979.html

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What a Facebook Re-Design Would Be Like in Real Life

By now we're mostly used to Facebook moving the furniture around every once in a while. We complain for a while, then just deal with it. But in a way, it's still maddening. Your stuff was HERE and now it's HERE. (Right, right, glass houses.) But at least Facebook can't barge in and rearrange your real life. That would be terrible. [YouTube]

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/LNU70RsyJks/what-a-facebook-re-design-would-be-like-in-real-life-502564802

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Michelle Knight, Kidnap Victim, Shuns Family Following Rescue

Source: http://www.thehollywoodgossip.com/2013/05/michelle-knight-kidnap-victim-shuns-family-following-rescue/

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Saturday, May 11, 2013

Gillmor Gang Live 05.10.13 (TCTV)

Gillmor Gang test patternGillmor Gang - Robert Scoble, John Taschek, Kevin Marks, Keith Teare, and Steve Gillmor. Recording live today at 1:30pm Pacific time.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4feGKx0fSHY/

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Great debut for Castro, Woods solid at Players

Tiger Woods hits from the seventh tee during the first round of The Players championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013, in Ponte Vedra Beach, Fla. (AP Photo/John Raoux)

Tiger Woods hits from the seventh tee during the first round of The Players championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013, in Ponte Vedra Beach, Fla. (AP Photo/John Raoux)

Roberto Castro hits from the ninth tee during the first round of The Players championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013, in Ponte Vedra Beach, Fla. Castro finished at 9-under-par 63, tying the course record. (AP Photo/Chris O'Meara)

Rory McIlroy, of Northern Ireland, hits from the 18th tee during the first round of The Players championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013 in Ponte Vedra Beach, Fla. (AP Photo/Gerald Herbert)

Roberto Castro shows his ball after finishing the first round of The Players championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013 in Ponte Vedra Beach, Fla. Castro finished at 9-under-par 63, tying the course record. (AP Photo/Gerald Herbert)

Tiger Woods reacts to his shot from the 11th fairway during the first round of The Players Championship golf tournament at TPC Sawgrass, Thursday, May 9, 2013, in Ponte Vedra Beach, Fla. (AP Photo/John Raoux)

(AP) ? Tiger Woods was nine shots out of the lead, not the best position at The Players Championship, especially since he had not even started his round. Perhaps the bigger surprise was the guy who posted the record-tying round Thursday.

Roberto Castro had only played the TPC Sawgrass in a practice round. He made a debut he won't soon forget.

There was the 9-iron to a foot on the island-green 17th and a 4-iron to about the same tap-in range on the 18th, the hardest hole on the course. He hit a 3-iron to 3 feet for eagle, and twice hit wedge so close he didn't even have to read the putt.

When his memorable day was over, Castro had a 9-under 63 and his name in the record book twice. He tied the course record held by Fred Couples and Greg Norman, and his three-shot lead was the largest margin after the opening round at The Players in 21 years.

Welcome to Sawgrass.

"I hit it close a lot," said Castro, making it sound as easy as it looked.

He led over Rory McIlroy, who broke par for the first time in his fourth appearance with five birdies after the turn and conservative play off the tee on the front nine for a bogey-free 66. Zach Johnson also had a 66 while playing in the pristine morning conditions.

Woods had to work a little harder in the afternoon. Not only did he spot Castro nine shots, Woods had never broken 70 in the opening round in his 15 previous tries.

"It was a day that I felt I had to shoot something in the 60s," Woods said.

He ran off four straight birdies around the turn. He was on the cup of his first bogey-free round at The Players until his 8-iron from 200 yards went just over the green and he flubbed his chip. The bogey gave him a 67, a strong effort considering he knew he had a lot of ground to make up before hitting his first shot.

"I've seen that a lot, but not at this golf course," he said.

Vijay Singh, playing one day after he sued the PGA Tour for its handling of his doping case, was largely ignored while playing in the group behind Woods. One fan wore felt deer antlers in the bleachers behind the first tee ? Singh's case involved taking deer antler spray ? but only a dozen or so people followed the 50-year-old Fijian on the back nine and it was a quiet day.

At one point, Singh let out a hearty laugh walking off the tee with Robert Garrigus and J.J. Henry. His golf wasn't the subject of the laughter. Singh hit into the water on the last hole and made bogey for a 74, leaving him in danger of missing the cut.

So ended a first round filled with plenty of action ? a record-tying score by a player hardly anyone knows, McIlroy breaking par for the first time at Sawgrass, 17 balls in the water around the island-green 17th and 33 rounds in the 60s. Padraig Harrington followed an eagle with a double bogey. Michael Thompson made a hole-in-one.

But it all started with Castro, a 27-year-old who felt like he couldn't miss.

"I don't think anyone has figured out what the secret is to this place," Castro said.

Woods, Webb Simpson and Ryan Palmer each had a 67, the lowest score from the afternoon.

McIlroy also played in the morning, in the same group as Masters champion Adam Scott (69) and Steve Stricker (67). The 24-year-old from Northern Ireland had never made the cut or even broken par at The Players, but McIlroy figured it out on a gorgeous morning by dialing it back off the tee and letting his iron play take over. McIlroy never came seriously close to a bogey, and he didn't hit driver once on the front nine.

"When you hit the shots, it seems very simple," McIlroy said. "I had a lot of good shots out there, lot of iron shots that were 12, 15 feet away from the pin and I got myself a lot of looks for birdies. I adopted maybe more of a conservative strategy off the tee this year. But once you put your ball in the fairway that means you can be more aggressive into the greens. So it sort of balances itself out."

The Stadium Course has rarely looked so vulnerable with barely a trace of wind and some pins in bowls that allowed for good looks at birdie. Half the 72 players in the morning broke par.

But the punishment is never far away, as Scott Stallings discovered. He opened with five straight birdies to get everyone's attention, but after going out in 31, Stallings gave most of it back with a bogey, double bogey and a triple bogey on the 16th when he hit two balls into the water. He shot 40 on the back for a 71.

"It just goes to show about the golf course and really how volatile it is," Stallings said.

Castro hasn't discovered that yet. This was a day when everything went right.

He made three birdies early in his round on the back until making his tap-in birdies on the 17th and 18th. Then, he hit 3-iron into 3 feet on the par-5 second hole for an eagle and was 7-under through 11 holes. On the fourth, he hit his approach inside 2 feet for another birdie, and then he hit wedge to 18 inches on the sixth.

Castro had a birdie putt just outside 12 feet to break the course record, but missed it.

After his eagle on the second hole ? his 11th of the round ? Castro was reminded of a game he plays to try to birdie every other hole.

"When I eagled, I was like, 'Oh, now I'm 7 (under) through 11, so that's keeping ahead of that 50 percent mark.' But this is a different golf course," he said. "The golf course is much harder than most of the other times I've kind of taken that attitude."

Couples shot his 63 in 1992 in the third round. Norman opened with a 63 in 1994 when he went on to shatter the tournament record at 24-under 264. Along with joining them in the record book, Castro matched the record set by Billy Ray Brown in 1992 with his three-shot lead after one round.

Castro is not well known even in golf circles. His mother grew up in Peru and moved to America as a teenager along with her sister, Jenny Lidback, who played the LPGA Tour. He toiled in the minor leagues for five years after getting his industrial engineering degree at Georgia Tech.

Woods wasn't pleased with how he struck the ball, only with where he missed it. Despite missing six greens, he was left with straightforward shots to save par. The only blemish came at the end, when his 56-degree wedge came up heavy into the grain and failed to reach the putting surface.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-09-GLF-Players-Championship/id-1cba8a17d28b4ec499f85d668c9dc329

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